Note: Precision viscosity measurement using suspended microchannel resonators

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Note: precision viscosity measurement using suspended microchannel resonators.

We report the characterization of a suspended microchannel resonator (SMR) for viscosity measurements in a low viscosity regime (<10 mPa s) using two measurement schemes. First, the quality factor (Q-factor) of the SMR was characterized with glycerol-water mixtures. The measured Q-factor at 20 °C exhibits a bilinear behavior with the sensitivity of 1281 (mPa s)(-1) for a lower (1-4 mPa s) and 3...

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We have demonstrated a new approach for detecting biomolecular mass in the aqueous environment. Known as the suspended microchannel resonator (SMR), target molecules flow through a suspended microchannel and are captured by receptor molecules attached to the interior channel walls [1]. As with other resonant mass sensors, the SMR detects the amount of captured target molecules via the change in...

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Precision frequency detection has enabled the suspended microchannel resonator (SMR) to weigh single living cells, single nanoparticles, and adsorbed protein layers in fluid. To date, the SMR resonance frequency has been determined optically, which requires the use of an external laser and photodiode and cannot be easily arrayed for multiplexed measurements. Here we demonstrate the first electr...

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Universal detectors that maintain high sensitivity as the detection volume is reduced to the subnanoliter scale can enhance the utility of miniaturized total analysis systems (mu-TAS). Here the unique scaling properties of the suspended microchannel resonator (SMR) are exploited to show universal detection in a 10 pL analysis volume with a density detection limit of approximately 1 microg/cm (3...

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ژورنال

عنوان ژورنال: Review of Scientific Instruments

سال: 2012

ISSN: 0034-6748,1089-7623

DOI: 10.1063/1.4768245